Publications

For an up-to-date list, see my google scholar profile.

Published articles and preprints (*Co-first author, #Co-corresponding author):

Selected articles:

  1. Kelemen M, Danesh J, Di Angelantonio E, Inouye M, O’Sullivan J, Pennells L, Roychowdhury T, Sweeting MJ, Wood AM, Harrison S, Kim LG. (2024) Evaluating the cost-effectiveness of polygenic risk score-stratified screening for abdominal aortic aneurysm. Nature Communications. PMID: 39277617

  2. Roychowdhury T*#, Klarin D*, Levin MG*, Spin JM , Rhee YH, Deng A, Headley CA, Surakka I, Tsao NL, Gellatly C, Zuber V, Shen F, Hornsby WE, Laursen IH, Verma SS, Locke AE, Einarsson G, Thorleifsson G, Graham SE, Dikilitas O, Pattee JW, Judy RL, Verges FP, Nielsen JB, Wolford BN, Brumpton BM, Dilmé J, Peypoch O, Juscafresa LC, Edwards TL, Li D, Banasik K, Brunak S, Jacobsen RL, Garcia-Barrio MT, Zhang J, Rasmussen LM, Lee R, Handa A, Wanhainen A, Mani K, Lindholt JS, Obel LM, Strauss E, Oszkinis G, Nelson CP, Saxby K, Herwaarden JV, Van der Laan SW, Setten JV, Camacho M, Davis FM, Wasikowski R, Tsoi LC, Gudjonsson JE, Eliason JL, Coleman DM, Henke PK, Ganesh SK, Chen YE, Guan W, Pankow JS, Pankratz N, Pedersen OB, Erikstrup C, Tang W, Hveem K, Gudbjartsson D, Gretarsdottir S, Thorsteinsdottir U, Holm H, Stefansson K, Ferreira MA, Baras A, Kullo IJ, Ritchie MD, Christensen AH, Iversen KK, Eldrup N, Sillesen H, Ostrowski SR, Bundgaard H, Ullum H, Burgess S, Gill D, Gallagher K, Sabater-Lleal M, DiscovEHR , Regeneron Genetics Center, UK Aneurysm Growth Study, DBDS Genomic Consortium, VA Million Veteran Program, Jones GT, Bown MJ, Tsao PS, Willer CJ#, Damrauer SM# (2023) Genome-wide association meta-analysis identifies risk loci for abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target. Nature Genetics. PMID: 37845353.

  3. Klarin D*, Devineni P*, Sendamarai AK*, Angueira AR, Graham SE, Shen YH, Levin MG, Pirruccello JP, Surakka I, Karnam PR, Roychowdhury T, Li Y, Wang M, Aragam KG, Paruchuri K, Zuber V, Shakt GE, Tsao NL, Judy RL, Vy HMT, Verma SS, Rader DJ, Do R, Bavaria JE, Nadkarni GN, Ritchie MD; VA Million Veteran Program; Burgess S, Guo DC, Ellinor PT, LeMaire SA, Milewicz DM, Willer CJ, Natarajan P, Tsao PS, Pyarajan S#, Damrauer SM# (2022) Genome-wide Association Study of Thoracic aortic aneurysm and Dissection in the Million Veteran Program. Nature Genetics. PMID: 37308786.

  4. Roychowdhury T*, Lu H*, Hornsby WE, Crone B, Wang GT, Guo D, Sendamarai A, Devineni P, Lin M, Zhou W, Graham SE, Wolford BN, Surakka I, Wang Z, Chang L, Zhang J, Mathis M, Brummett CM, Melendez TL, Shea MJ, Kim KM, Deeb MG, Patel HJ, Eliason J, Eagle KA, Yang B, Ganesh SK, Brumpton B, Åsvold BO, Skogholt AH, Hveem K, VA Million Veteran Program, Pyarajan S, Klarin D, Tsao PS, Damrauer SM, Leal SM, Milewicz DM, Chen EY, Garcia-Barrio MT#, Willer CJ#. (2021) Regulatory variants in TCF7L2 are associated with thoracic aortic aneurysm. American Journal of Human Genetics. PMID: 34265237.

  5. Nielsen JB*, Rom O*, Surakka I*, Graham SE*, Zhou W*, Roychowdhury T, Fritsche LG, Gagliano Taliun SA, Sidore C, Liu Y, Gabrielsen ME, Skogholt AH, Wolford B, Overton W, Zhao Y, Chen J, Zhang H, Hornsby WE, Acheampong A, Grooms A, Schaefer A, Zajac GJM, Villacorta L, Zhang J, Brumpton B, Løset M, Rai V, Lundegaard PR, Olesen MS, Taylor KD, Palmer ND, Chen YD, Choi SH, Lubitz SA, Ellinor PT, Barnes KC, Daya M, Rafaels N, Weiss ST, Lasky-Su J, Tracy RP, Vasan RS, Cupples LA, Mathias RA, Yanek LR, Becker LC, Peyser PA, Bielak LF, Smith JA, Aslibekyan S, Hidalgo BA, Arnett DK, Irvin MR, Wilson JG, Musani SK, Correa A, Rich SS, Guo X, Rotter JI, Konkle BA, Johnsen JM, Ashley-Koch AE, Telen MJ, Sheehan VA, Blangero J, Curran JE, Peralta JM, Montgomery C, Sheu WH, Chung RH, Schwander K, Nouraie SM, Gordeuk VR, Zhang Y, Kooperberg C, Reiner AP, Jackson RD, Bleecker ER, Meyers DA, Li X, Das S, Yu K, LeFaive J, Smith A, Blackwell T, Taliun D, Zollner S, Forer L, Schoenherr S, Fuchsberger C, Pandit A, Zawistowski M, Kheterpal S, Brummett CM, Natarajan P, Schlessinger D, Lee S, Kang HM, Cucca F, Holmen OL, Åsvold BO, Boehnke M, Kathiresan S, Abecasis GR, Chen YE, Willer CJ #, Hveem K # (2020) Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease. Nature Communications. PMID: 33339817.

  6. Roychowdhury T, Abyzov A. (2019) Chromatin organization modulates the origin of heritable structural variations in human genome. Nucleic Acids Research. PMID: 30773596.

  7. Amiri A*, Coppola G*, Scuderi S*, Wu F*, Roychowdhury T*, Liu F, Pochareddy S, Shin Y, Safi A, Song L, Zhu Y, Sousa AM, PsychENCODE consortium, Gerstein M, Crawford GE, Sestan N, Abyzov A#, Vaccarino FM#. (2018) Transcriptome and epigenome landscape of human cortical development modeled in brain organoids. Science. PMID: 30545853.

  8. Bae T, Tomasini L, Mariani J, Zhou B, Roychowdhury T, Franjic D, Pletikos M, Pattni R, Chen BJ, Venturini E, Riley-Gillis B, Sestan N, Urban AE, Abyzov A#, Vaccarino FM#. (2018) Different mutational rates and mechanisms in human cells at pre-gastrulation and neurogenesis. Science. PMID: 29217587.

Other articles:

  1. Zhou B, Purmann C, Guo H, Shin GW, Huang Y, Pattni R, Meng Q, Greer SU, Roychowdhury T, Wood RN, Ho M, Dohna H, Abyzov A, Hallmayer J, Wong WH, Ji H, Urban AE. (2024) Resolving the 22q11.2 deletions using CTLR-Seq reveals chromosomal rearrangement mechanisms and individual variance in breakpoints. PNAS. PMID: 39042694.

  2. Adkar S, Lynch J, Choi RB, Roychowdhury T, Judy RL, Paruchuri K, Go DC, Bamezai S, Cabot J, Sorondo S, Levin MG, Milewicz DM, Willer CJ, Natarajan P, Pyarajan S, Chang KM, Damrauer S, Tsao P, Skirboll S, Leeper NJ, Klarin D. (2023) Dissecting the genetic architecture of intracranial aneurysms. MedRxiv. doi.org/10.1101/2023.07.30.23293390

  3. Mandal S, Roychowdhury T, Bhattacharya A. (2021) Pattern of genomic variation in SARS-CoV-2 (COVID-19) suggests restricted nonrandom changes: Analysis using Shewhart control charts. Journal of Biosciences. PMID: 33709963.

  4. Zhou W, Brumpton B, Kabil O, Gudmundsson J, Thorleifsson G*, Weinstock J, Zawistowski M, Nielsen JB, Chaker L, Medici M, Teumer A, Naitza S, Sanna S, Schultheiss UT, Cappola A, Karjalainen J, Kurki M, Oneka M, Taylor P, Fritsche LG, Graham SE, Wolford BN, Overton W, Rasheed H, Haug EB, Gabrielsen ME, Skogholt AH, Surakka I, Davey Smith G, Pandit A, Roychowdhury T, Hornsby WE, Jonasson JG, Senter L, Liyanarachchi S, Ringel MD, Xu L, Kiemeney LA, He H, Netea-Maier RT, Mayordomo JI, Plantinga TS, Hrafnkelsson J, Hjartarson H, Sturgis EM, Palotie A, Daly M, Citterio CE, Arvan P, Brummett CM, Boehnke M, de la Chapelle A, Stefansson K, Hveem K, Willer CJ#, Asvold BO# (2020) GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse genetic association with thyroid cancer. Nature Communications. PMID: 32769997.

  5. Roychowdhury T, Singh VK, Bhattacharya A. (2018) Classification of pathogenic microbes using a minimal set of single nucleotide polymorphisms derived from whole genome sequences. Genomics. PMID: 29432978.

  6. Biswal DK, Roychowdhury T, Pandey P, Tandon V. (2018) De novo genome and transcriptome analyses provide insights into the biology of the trematode human parasite Fasciolopsis buski. PLoS One. PMID: 30325945.

  7. Mandal S, Roychowdhury T, Chirom K, Bhattacharya A, Singh RKB. (2017) Complex multifractal nature in Mycobacterium tuberculosis genome. Scientific Reports. PMID: 28440326.

  8. Roychowdhury T#, Mandal S, Bhattacharya A#. (2015) Analysis of IS6110 insertion sites provides a glimpse into genome evolution of Mycobacterium tuberculosis. Scientific Reports. PMID: 26215170.

  9. Kumar M, Prasad NG, Roychowdhury T, Thakur PK, Banakar P, Shukla RN, Jones MG, Rao U. (2014) De novo Transcriptome sequencing and Analysis of the Cereal Cyst Nematode, Heterodera avenae. PLoS One. PMID: 24802510.

  10. Roychowdhury T, Vishnoi A, Bhattacharya A. (2013) Next-Generation Anchor Based Phylogeny (NexABP): Constructing phylogeny from Next-generation sequencing data. Scientific Reports. PMID: 24022334.

  11. Das S, Roychowdhury T, Kumar P, Kumar A, Kalra P, Singh J, Singh S, Prasad HK#, Bhattacharya A#. (2013) Genetic heterogeneity revealed by sequence analysis of Mycobacterium tuberculosis isolates from extra-pulmonary tuberculosis patients. BMC Genomics. PMID: 23773324.

Articles as consortium author:

  1. Hu B et al. (2021) Neuronal and glial 3D chromatin architecture informs the cellular etiology of brain disorders. Nature Communications. PMID: 34172755

  2. Gandal MJ et al. (2018) Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder. Science. PMID: 30545856.

  3. Li M et al. (2018) Integrative functional genomic analysis of human brain development and neuropsychiatric risks. Science. PMID: 30545854.

  4. Wang D et al. (2018) Comprehensive functional genomic resource and integrative model for the human brain. Science. PMID: 30545857.